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Information × Registration Number 0201U003378, 0198U005184 , R & D reports Title То study the regularity of interaction of tumor and immunocompetent cells in dependence of tumor cell biological peculiarity and its influence to the lymphocyte functional activity popup.stage_title Head Berezhna N.M., Registration Date 21-02-2001 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Investigation have been done on mice BALB/c and C57BL/6 with transplanted MH-rabdomiosarcoma and B16 melanoma, and also in clinical material from patients with skin melanoma and patient with soft tissue tumors. These tumor cells and autologous mouse lymph nodes lymphocytes and patients periferal blood lymphocytes were the subject of investigation. It was shown, that lymphocyte antitumor activity in mice with different tumor growth models have substantial distinctions in comparison with its tumor growth dytnamic and also by different models in condition of transplanted MH-rabdomiosarcoma lymphocyte antitumor activity have been combined with high level CD54 expression on lymphocytes and IgM and CD54 on tumor cells, at melanoma - CD54 expression on lymphocytes and proliferative marker on tumor cells. Proliferative and activative expression on patients tumor cells with melanoma do not depend from stage of tumo growth, adhesive molecule CD54txpression are correlate Product Description popup.authors popup.nrat_date 2020-04-02 Close