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Information × Registration Number 0201U003806, 0100U003320 , R & D reports Title Investigation of the role of mitochondrial proapoptic factors release in mechanisms of geropromotive action of xenobiotics. popup.stage_title Head Lemeshko V.,Padalko V., Registration Date 26-04-2001 Organization Kharkov National University named after V.N.Karazin popup.description2 Objects:fruit fly Drosophila melanogaster.Purpose: investigation of xenobiotics participation in accelerated ageing induction (in particular ,contribution in this process the proapoptotic mitochondrial factors release).Results:on the basis of modern (1995-2000) data of literature , the analysis of contemporary notion about the programmed cell death (apoptosis) mechanisms ,the role of mitochondria (mitochondrial proapoptotic factors) in apoptosis induction ,the correlation between the apoptosis,ageing and age -related patology was made ,Separately the apoptosis triggering by environmental chemicals and drugs was discussed .The preliminary results about correlation between fly lifespan,the phenobarbital (the apoptosis intensivity modulator ) treatment and belonging of insects to different populations with different duration of sleeping after enter narcosis were obtained in this investigation. Product Description popup.authors popup.nrat_date 2020-04-02 Close