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Information × Registration Number 0201U004361, 0198U007228 , R & D reports Title Development of methods of synthesis and research of properties of the оligonucleotides covalently modified by intercalators of phenasine derivatives popup.stage_title Head Fedoryak D.M., Registration Date 21-03-2001 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 Oligonucleotides modified by imidazophenasine nucleosides complementary to sites of ribosome operone both 16S rRNA of micoplasma and E.coli are received. It was shown, that nucleosides of imidazo[4,5-b]phenasine and its 2-methyl analogue, working as effective intercalators, assentially influence stability of complementary duplex, raising antisense activity of oligomers. The influence covalently attached dye on formation of complementary complexes is investigated. Product Description popup.authors popup.nrat_date 2020-04-02 Close