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Information × Registration Number 0201U004800, 0198U004907 , R & D reports Title The optimization of the search and studies of the most effective combinations of radioprotective drugs, natural in origin popup.stage_title Head Rudnyev Mykhajlo Ivanovych, Registration Date 23-04-2001 Organization Research Centre for Radiation Medicine popup.description2 The experiments were carried out with 298 male rats. The aim of the research: search and studies of the most effective combinations of known and potential radioprotective drugs of natural origin in animals experiment using mathematical multifactor experiments planning. Research methods: biochemical, radiometrical, neurophysiological, statistical. It was found that metabolites of tricarbon cycle (succinate, cytrate, malate) interect both among themselves and with radiation factor This interaction is of types: synergism, additive, domi-nante, and antagonism.The efects of increase in hemoglobin and blood erthrocyte under succinate efect were found. It was confirmed radioprotective effectiveness of optimal combinations of succinate and malate, and their mechanisms of action were studied. Effect of citrate were found to be inconsistent, therefore at present it can not be included into radioprotective combinations. Product Description popup.authors popup.nrat_date 2020-04-02 Close