Search academic texts

Information × Registration Number 0202U000323, 0199U003083 , R & D reports Title Development and Implementation into Clinical Practice of the Health Improving Meens for the Critical Pоpulation Groups that Suffered as a Result of Chеrnobyl accident popup.stage_title Head Rudnyev Mykhajlo Ivanovych, Registration Date 31-01-2002 Organization Research Centre for Radiation Medicine popup.description2 Object: a blood 92 suffering owing to failure on Chernobyl station and control persons, 748 white rats, 30 white mice, 6 rabbits. The purpose: To estimate a chromosomal state of the device of somatic cells and biochemical risk factors of development of an atherosclerosis in critical groups of the population and to prove correction of the revealed infringements. To investigate influence of an ionizing radiation on a state of metabolic activity and genetical damages of cells of hemopoietic system and blood. To frame a complex radioprotective agent on the basis of beta-Carotinum and Acidum folicum for the prevention of unfavorable consequences of influence of an ionizing radiation in a complex with other unfavorable factors of environment. 3. To develop the references. At cytogenetic inspection 22 persons are analysed 6400 metaphases of culture of leucocytes of the inhabitants of regions, accumbent to NPP. Rising markers of radiative influence is revealed, that specifies on radiation induced cytogenetic e ffect. In experiment the changes of a motor performance, working capacity, ability to learning and memory of animals irradiated in a dose 0,1 that 0,5 Gy are investigated and animals, which were irradiated with the same dose on a background of Pyracetamum. Fixed, that Pyracetamum and Cerebrocurin, normalized energy metabolism, raise resistance a CNS to influence of an ionizing irradiating in small doses. Betа-Carotinum and Acidum folicum in conditions of the combined influence of an ionizing irradiating and Pb, 3. Normalized processes oxidative phosphorilation in a brain and liver rats fixed, that. The age laws of reactions of processes of histic respiration on an irradiating and Pb fixed. Is shown, that a brain and liver at irradiated rats are more sensitive to influence Pb, than at usual animals. Fixed, that Beta-Carotinum effectively reduced the contents MDA in tissues, and Acidum folicum - in a blood in conditions of influence of the researched factors. The complex preparation of Beta-Carotinum and Acidu m folicum in conditions of influence of the large dose of an ionizing radiation renders antioxidant effect. The acute and chronic toxicity of a complex preparation is investigated Both experimental, and the clinical and biochemical researches, testify to infringement of a metabolic homeostasis of an atherosclerotic orientation at influence of ionizing radiation and are a chemical risk factor of development of atherosclerotic lesions in an organism. Is developed microcalorimetry a method of gauging of an integral blood and hemopoietic tissue, higher metabolic activity of leucocytes is found. 3. Both experimental, and the clinical and biochemical researches, testify to infringement of a metabolic homeostasis of an atherosclerotic orientation at influence of ionizing radiation and are a chemical risk factor of development of atherosclerotic lesions in an organism. Is developed microcalorimetry a method of gauging of an integral blood and hemopoietic tissue, higher metabolic activity of leucocytes is found. Product Description popup.authors popup.nrat_date 2020-04-02 Close