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Information × Registration Number 0202U004048, 0199U003067 , R & D reports Title Development of Measures of Prophylaxis, Diagnostic and Treatment of the People, Suffered from the Chernobyl Catastrophe (complex study) popup.stage_title Head Bazyka Dmytro Anatolijovych, Registration Date 31-01-2002 Organization Research Centre for Radiation Medicine popup.description2 People who live in Contaminated area, liquidators of Chernobyl accident. To study the genito-urinary organ condition in those who live in contaminated area. System elaboration for the account of organism functional condition. The dependence between emphasis of morphological and immune hysto chemical changes of prostate and urinary bladder epithelium, frequency of gene р53 mutations, the level of the territorial contamination of and by the amount urine contamination of by Cs137 in examined group of patients is established. On contaminated by radionuclides territories patients with non-malignant hyperplasia of prostate, which are indicated prostate intraepithelial neoplasia, make the high risk group for the development of invasive prostate cancer. Frequent* gene р53 mutations and its specific feature in damaged urothelium of urine bladder admitted to choose patients with chronic cystitis into the high-risk group of the development of urine bladder cancer. The changes of immune, antioxidant and energy sys tems in 93 patients, who underwent acute radiation sickness and in patients with leukaemia, were found. By means of mathematical information and software algorithmic provision the organism functional condition is analysed. The method to account of several links of organism functional state regulation systems condition and the balance is created.. Two times eye examination is made in 11403 liquidators of ChAPP accident by the use of special equipment and with following account the dependence of the dynamics of the clearing of crystalline lens eye variations from gained dose is accomplished. The usage of 'case-control' method admitted to demonstrate the dependence of cataract appearance from irradiation dose levels in three age groups for the first time and to develop the method of prognosis of cataract in the employees exhibited professional irradiation. The availability of probable structural-functional and metabolic changes in dyencephalo-stem parts of brain in irradiated animals depending on their sex and a ge is established. The peculiarities and discrepancies of postirradiation encephalopathy in liquidators, in dependence from the irradiated dose and the durability of radiation ascendant, sex and age are indicated. Common brain disorders in children descendants of liquidators and those who abided on contaminated areas is also found. * The functional condition and spare opportunities of hypothalamic - hypophysis - thyroid and hypothalamic-hypophysis adrenal, prolactinsecretic and immune systems in 430 people of critical groups is examined. The diagnostic complex that includes obligatory administration during the check up of offered plans of clinical, hormone, immune and instrumental explorations that gives opportunity to indicate the disturbance of these systems is developed. On the grounds of given diagnostic complex the system of treatment that admits of maximally individual therapeutic approach to every patient, to ameliorate the effects of the treatment of patients on radiation dependent thyropathy, to boos t their rehabilitation is developed. Product Description popup.authors popup.nrat_date 2020-04-02 Close