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Information × Registration Number 0203U000372, 0102U001816 , R & D reports Title Pharmacological study of isobenzofuranones - the new class of compounds with antithyroid effect popup.stage_title Head Bozshko Tatiana Stepanovna, Registration Date 03-02-2003 Organization V.Danilevsky Institute of Endocrine Pathology Problems Academy of Medical Sciences of Ukraine popup.description2 Оbject of research - new biologically active compounds from izobenzofuranone series. The aim - the new generation antitheroid drug creation experimental substantiation. The methods - pharmacological, toxycological, hystological, morphometrical, radioimmunological, enzyme immunoassay tests, chemical, physic-chemistry. In result it has been shown, the substances JV-18 directly influenced on the thyroid gland functional activity, whereas compound JV-14 action extend sends on peripheryc links of the pituitary- thyroid system regulation. The both of tested compounds do not caused toxicological changes. It was recommendated the infurther pre-clinical investigation for a modern high antithyroid activity drug production carrying out. Range of application - pharmchemistry, endocrinology Product Description popup.authors popup.nrat_date 2020-04-02 Close