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Information × Registration Number 0203U000436, 0198U001314 , R & D reports Title Structure-functional investigation of eukaryotic tyrosyl-tRNA synthetase by methods of protein engineering popup.stage_title Head Kornelyuk Alexander Ivanovich, Registration Date 06-02-2003 Organization Institute of molecular biology & genetics popup.description2 Investigation of mammalian tyrosyl-tRNA synthetase (TyrRS) was carried out by methods of protein engineering. Spatial structure of the synthetase was obtained by homology modeling approach. Lys147 is important for tRNATyr aminoacylation reaction. New function was found - cytokine activity of the mammalian TyrRS C-module, which is homologous to cytokine EMAP II and shows synergizm of action with tumor necrosis factor. Product Description popup.authors popup.nrat_date 2020-04-02 Close