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Information × Registration Number 0203U000939, 0100U000630 , R & D reports Title Determination of cytology and immunophenotype peculiarities of chronic lymphoproliferative diseases in persons subjected the ionizing radiation action popup.stage_title Head Gluzman D.F., Registration Date 27-03-2003 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Malignancies of hemopoietic and lymphoid tissue developing in Chernobyl clean-up workers have been studied in accordanse with new WHO classification. Practically all the main forms of hemablastoses were registered, and the predominance of chronic lymphoproliferative diseases of B-cells origin (94,3%), including B-CLL (55%), which until recently has not been regarded as radiation-associated leukemia. High prevalence of multiple myeloma, hairy cell leukemia and LGL leukemia also has been noticed. Reactive changes of bone marrow stroma with appearance alcaline phosphatase positive dendritic cells seems to represent the characteristic features of hemoblastoses under study. It has been noticed predominance of agressive forms of B-CLL in Chernobyl clean-up workers and diese may be propose by use of wide panel of monoclonal atibodies, including CD11b and CD11c. Product Description popup.authors popup.nrat_date 2020-04-02 Close