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Information × Registration Number 0203U002261, 0101U007611 , R & D reports Title Pathogenesis of the metabolic disturbances under the excessive nitric oxide production from endogenic and exogenic precursors popup.stage_title Head Kostenko Vitaliy Alexandrovich, Registration Date 19-02-2003 Organization Ukrainian Medical Stomatological Academy of Ministry of Public Health of Ukraine popup.description2 Is revealed, that the exogenous introduction of sodium nitrate (200 mg/kg of mass of a body of white rats) results in accumulation of nitric oxide in tissues (salivary glands, testicles) as Fe-NO complexes. The surplus NO formation results in progressing decrease of ATP concentration, energy potential, oppression of activity of respiratory chain enzymes, uncoupling of mitochondrial oxidation and phosphorylation ADP (on 30 and 90 days of chronic nitrate intoxication). In dynamics of chronic sodium nitrate intoxication in salivary glands and testicles of white rats we observed the progressing augmentation of production of superoxide anion-radical by mitochondrial and microsomal electron-transport chains. The chronic intoxication with sodium nitrate results in development of dystrophical changes of spermatogenic epithelium and disturbances of microcirculation. The modelling of acute carrageenin inflammation in tissues salivary glands results in endogenic NO and its accumulation, that renders immediateinfluence on energy metabolism, decrease processes mitochondrial oxidation and phosphorylations in tissues of salivary glands. The purpose of hyperbaric oxygenation limits penetrating infringement of mitochondrial respiration, phosphorylation, limits accumulation of nitric oxide, prevents an essential activation of lipid peroxidation. Product Description popup.authors popup.nrat_date 2020-04-02 Close