Search academic texts

Information × Registration Number 0203U008047, 0100U003323 , R & D reports Title Role of heme and hemoproteins in regulation metabolic adaptation system under oxidative stress. popup.stage_title Head 3.Khaliman P.A., Registration Date 11-04-2003 Organization Kharkov National University named after V.N.Karazin popup.description2 The aim of this study was to investigate the role of heme and hemoproteins in the regulation of adaptation system under the oxidative stress.Subject of this investigation -heme and lipid metabolism,the antioxidant activities in rats organs and tissues and blood serum under the oxidative stress.The heme oxygenase,delta-aminolevulinate syntase, some hemoprotein activities,some parameters of antioxidant-prooxidant equilibrium and lipid metabolism in different organs of rats and absorption spectrum blood serum in Soret region under metal salts administration. The Wistar rats were used in the work.Treatment with CdCl2 and HgCl2 caused the hemolysis products accumilation in blood serum and their further transport into the liver and kidney. The increase of heme-binding protein tryptophan - 2,3-dioxygenase content makes less expressed oxidative disorders,caused by free heme,which accumilates in liver after HgCl2 administration.Alpha-Tocopherol administration prevent antioxidant -prooxidant equilibrium changes and did not prevent the increase heme oxygenase activity and accumilation of hemolys products caused CdCl2, Product Description popup.authors popup.nrat_date 2020-04-02 Close