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Information × Registration Number 0203U008048, 0100U003320 , R & D reports Title Investigation of the role of mitochondrial proapoptic factors release in mechanisms of geropromotive action of xenobiotics. popup.stage_title Head 3.Lemechko V.V.,Padalko V.I, Registration Date 11-04-2003 Organization Kharkov National University named after V.N.Karazin popup.description2 There was shown the ability of xenobiotics to promove the premature ageing of organism, the direction of this action being assentially dependent on the dose of the agent.It was esteblished that exposure of yeast cells to different influences provoking one or another form of stress led to significant,dependent of the dose and duration of action, depression of population growth, essential damage of cells,decrease of intensity of oxygen consumption and increase of quantity of cells with fragmented DNA ,that probably connected with the prooxidant effect of these factors.There was made the conclusion about the enough essential information value of the used ''yeast'' model for the characterisation of the extent of the pro-apoptotic action of environmental factors. The obteined results confirm the standpoint about the universal character of oxidative stress in the mechanisms of exogenic factors effects,but the other mechanisms are also perminent and the experiments with the use of NO- radicals donors testify this fact. Product Description popup.authors popup.nrat_date 2020-04-02 Close