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Information × Registration Number 0203U008744, 0101U002690 , R & D reports Title Functioning macrophage-helper chain of immunity for early stages of diabetes mellitus developing. popup.stage_title Head Malyzhev V.O., Registration Date 26-12-2003 Organization Ukrainian scientific and practical center of endocrine surgery, transplantation of endocrine organs and tissues popup.description2 The diabetes mellitus type 1 is caused not only by inheritance and trigger invironmental factors, but an inducible ac tivation of interleukin 12 synthesis. It's determination is very important for the treatment prognosis. It wae demonstrated that on the level of the first clinic manifestations of diabetic mellitus the contence of the proinflammation cytokines(IL1 and TNF) in peripheral blood was correlated with intersivity of autoimmune reactions. These can be used for monitoring of specific inflammation processes. The increased level of proinflammation cytokines that were determinated the level of resistance to insulin and character of beta-cells fuctioning has placed and during development of diabetes mellitus type2. On the basis of received data it was proposed the obligatiry including in therary both pathologies the preparations with proinflammatory actions, the antioxidants and means with capacity to regulate the activity of basis subpopulations of T-helper and macrophages5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close