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Information × Registration Number 0204U000200, 0101U000358 , R & D reports Title Studying the influence of 2'-5' olygoadenilates (2'-5'A3) analogues on phosphodiesteraze cAMP activity and on the concentration of cyclic nucleotides on the basis of imunosupression in organs and animal tissues. popup.stage_title Head Маtcuка G.Kh., Ткаchuк Z.Yu., Registration Date 22-01-2004 Organization Institute of molecular biology & genetics popup.description2 Report on NDR: 60 p., 5 illustrations, 6 tables, 40 references It is concluded that transplantation of kidneys in animals are accompanied by significant increases of phosphodiesteraze cAMP activity in animals' blood and wavy changes in concentration of cyclic nucleotides, that can be normalized by intravenous injection of 2',5'-ApApAepo. Such normalization of cAMP/cGMP system components provides an ability to prevent kidney seizure during acute and chronic phase of transplant seizure decease. Received results allow to recommend substance 2',5'-ApApAepo for clinical tests as imunosuppressor during transplantation of organs and tissues in humans. 2',5' olygoadenilates, cyclic AMP, cyclic GMP, phosphodiesteraze, imunosuppresion, T-lymphocites, blood plasma, kidneys. Product Description popup.authors popup.nrat_date 2020-04-02 Close