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Information × Registration Number 0204U000218, 0101U001451 , R & D reports Title The studying of allergic inflammation mechanisms in development of immuno-dependent somatic pathology in liquidatiors of Chernobyl accident popup.stage_title Head Bazyka D.A., Доктор медичних наук Registration Date 22-01-2004 Organization Research Centre for Radiation Medicine popup.description2 The purpose: development immunological infringements correction expedients and search of a reactivity modulators on the basis of updating cell mechanisms study, hypersesitivity responses at allergic inflammatory processes formation in the patients with immunedependent somatic pathology, which have undergone to influence of ionizing radiation.The object: - 271 clean-up workers of Chernobyl failure (their peripheric blood, Serum, plasma and blood cells). Methods: clinical-immunological screening, profound study of a immune system state, statistical. The results: formation of changed sensitivity responses at the patients with immunedependent somatic pathology on the basis of a separate subpopulations responses complex of immunocompetent cells. The blanket mechanisms include presence of cell responses such as to antigenes of a microbial parentage and relevant tissue antigenes: expression modulation of activation antigenes, oppression of activation responses. The particular diversions - ascending of numbercytotoxic cells, which concern to CD8 + lymphocytes, connection of CD4 + cells levels changes and relation CD4 +/CD8 + lymphocytes with exposed doses if radiation, oppression or dyscoordination of immunocompetent cells activation process with change of percent of cells, which expressed early antigenes of activation - CD71, CD25 and HLA-DR. Experimental beforeclinical examinations in vitro fixed, that at cell activation of exogenous cultures by recombinent interleukines - by fissile substances - N-acetylstearoilamine and „ super Erbisol" are possible different on phenotype variants of the answer Th1 and - or Th2 subpopulations. The effect of „ super Erbisol" at patients, which havebeen irradiated in doses which are not exceeding 50 sGy, includes mainly Th2- response, in irradiation in doses exceeding 50 sGy - formations as Th1, and Th2 responses. Product Description popup.authors popup.nrat_date 2020-04-02 Close