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Information × Registration Number 0204U003150, 0101U000953 , R & D reports Title Determination of the role of monooxygenation system and lipoperoxidation changes by prognosing of toxicity of potential medical agents for correction of different endocrinopathies popup.stage_title Head Kolodub F., Kudrya M., Registration Date 10-02-2004 Organization Ukrainian Research Institute of Endocrine Diseases Pharmacotherapy popup.description2 Object of research: rats, amides of succinic acid, diacamph. The aim is determination of features of biochemical mechanisms of possible damaging action of dicarboxylic acids derivatives with the determined specific action on organism. Methods: chemical, toxicological, biochemical. Phensuccinalum and 6 amides of succinic acid which have hypoglycemic and/or antioxidative properties are synthesized and certificated. Researches of influence of compounds on the contents of the basic components monooxigenasic system (MOS), state of free-radical processes and lipoperoxidation (LP) in experiences in vitro and in vivo are carried out within the subchronic peroral and inhalatory expositions. Intensification of processes of LP of the microsomal membranes owing to their activation electrontrasport chain is the main biochemical mechanism of potential toxicity of investigated derivative succinic and camphor acids. Field of application: toxicology Product Description popup.authors popup.nrat_date 2020-04-02 Close