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Information × Registration Number 0204U003223, 0101U002030 , R & D reports Title Effects of NMDA-receptor antagonists and alpha-adrenoblockers on brain functioning and explore a possibility for their use in complex pathogenetic therapy of Parkinson's disease popup.stage_title Head I.N.Karaban, Registration Date 18-02-2004 Organization Institute of Gerontology popup.description2 The work has been aimed, firstly, to study effects of the antagonists, NMDA-receptors and alpha-adrenoblockers, on the brain functioning and, secondly, to elucidate possibilities of their use in complex pathogenetic therapy of Parkinson's disease. To this end, the patients underwent clinical-neurological examination, transcranial ultrasound dopplerography, and brain constant potential level. Based on the results obtained, the authors have grounded the differential use of glutamate receptor antagonists (PK-Merz) under conditions of levodopa therapy tolerance and alpha-adrenoblocker (Nicergoline) action, both of which normalise the cerebral hemodynamics and reduce the motor dysfunction pronouncement and patients' disability degree. Product Description popup.authors popup.nrat_date 2020-04-02 Close