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Information × Registration Number 0204U003359, 0100U000297 , R & D reports Title Study biotransformation mechanisms of the pharmacological substances of aromatic series combinations metabolizing with P450 2E1 cytochrome and basis the directions of their toxicological reduction by hepatic exchange correction popup.stage_title Head Kovalenko Valentina Mykolaivna, Кандидат економічних наук Registration Date 11-03-2004 Organization Institute of Pharmacology and Toxicology Academy of Medical sciences of Ykraine popup.description2 Activity of cytochrome P450-dependent momooxygenases, some enzymes of miticondria, state of pro- and antioxydant systems of rat liver and their role in the development of paracetamole and isoniaside have been studied at isolated introduction and with chronic alcoholism, experimental hepatitis, combination with coffeine and rifampicine.In serum of experimental animals biochemical parameters of liver damage were investigated(AlAT, AsAT, bilirubin, cholesterol). It was established, that introduction to rats toxic doses of paracetamole and isoniaside alone or with chronic alcoholism, experimental hepatitis or in combination with coffeine or rifampicine was accompanied with induction of microsomal monooxygenases activities, increase of free radical processes activities in liver and decomposition of its structure-functional state. It was shown that use of experimental composition with metabolic action at such conditions assisted liver metabolism correction and partial prevention of xenobiotics toxic effectsdevelopment.5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close