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Information × Registration Number 0204U003475, 0101U001860 , R & D reports Title Optimisation tactics of intensive care for children in critical states cosed by infection aggresion popup.stage_title Head Georgiyants Marine Akopovna, Registration Date 26-03-2004 Organization The Kharkiv Post-graduate Medical Academy popup.description2 The hypertonic-hyperoncotic solution (combination of 10% NaCl solution with 6% pentastarch in proportion 1:1, doze 8 ml on kg of body weight) were used for resuscitation in pediatric severe sepsis and septic shock. They (vs. isotonic salt solution, 6% hetastharch and combination of 10% NaCl solution with dextran 40) promotes fast increase preload, pump function of left heart, decrease afterload and increase cardiac output and oxygen delivery. The hypertonic pentastharch solution are eliminated stress-reaction (decrease a cortisole and glycemia level and increase insuline level), and severe acidosis. The hypertonic-hyperoncotic solution are not cause essential and prolonged hyperosmolarity and increase sodium plasma level. They are increase kidneys excretion sodium and osmolal active substances, improve glomerular filtration and eliminated a shock caused increase antidiuretic hormone activiti. A combination of 10% NaCl solution with 6% pentastharch promotes faster reduction of MODS and decrease deas rate at children with severe forms of infection pathology which complicated septic shock and severe sepsis up to 11,1% in comparison from 50,0% at use isotonic salt solution, 41,2% at use pentastharch 200 and 36,8% at use dextran 40/10% sodium chloride solution. Product Description popup.authors popup.nrat_date 2020-04-02 Close