Search academic texts

Information × Registration Number 0204U003495, 0101U000155 , R & D reports Title To determine risk factors and mechanisms of pubertal period hypothalamic syndrome progression during puberty in boys. popup.stage_title Head Plekhova Helena Igorevna, Registration Date 09-04-2004 Organization Institute of Children and Adolescents Health Care Protection of Ukrainian Academy of Medical Science popup.description2 Subject: the study include 209 boys, aged 10-17 years, with pubertal period hypothalamic syndrome (PPHS). Objective: improving early diagnostics, prognosing the course of the disease and scientific substantiation approaches to PPHS treatment on the basis of determining risk factors of its formatoin and mechanisms of its progress in puberty. Methods: clinical, biochemical, radioimmunological, immunofermentative, clinico-genealogical, immuno-genetic, dermaglyphic. Theoretical and practical results and novelty: On the basis of determining PPHS clinical manifestations in boys 4 variants of the disease were singled out. Certain disorders in monoaminergic control of pituitary tropic functions in patients with PPHS were established. The role of melatonin in the development of hormonal and metabolic disorders was confirmed. It was established that in puberty in the patients with PPHS a moderate hypercorticoidism is formed. Negative dynamics of gonadotropic and sex hormones, hyperinsulinemia and hyperleptinemia are the factors of dyslipoproteinemia progression and of collagenase and elastase activation. PPHS in boys was proved to be a multifactorial disease its formation being affected both by environmental and by hereditary factors. Accumulation of multifactorial pathology was revealed in families with the boys suffering from PPHS (hypertension, obesity and type II diabetes mellitus) and with prevalence of said pathology in the relatives of first to third degree of relationship in maternal strain only and in both strains of relationship at the same time. The presence of associative links between the class I antigens of HLA system and PPHS formation was established. The antigens that can contribute PPHS formation include A11, А24, А25, В16, В51 antigens. Quantitative and qualitative dermatoglyphic signs characteristic of PPHS were revealed. Effectivity: improving early diagnostics PPHS in boys. Field of application: pediatrics, endocrinology, genetics. Product Description popup.authors popup.nrat_date 2020-04-02 Close