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Information × Registration Number 0204U003547, 0104U003476 , R & D reports Title Modulation the ligand-operated channels in CNS neurons. popup.stage_title Head Krishtal Oleg O., Registration Date 24-03-2004 Organization International center of molecular physiology popup.description2 For the accounting period was carried out researches of modulation ligand-controlled NMDA- and GAMK-receptor-operated of channels in a membrane neurons CNS in normal and pathology conditions. The mechanisms of blocking GAMK-receptors by derivative aminobenzophenon 5-brom -2-amin -2 '-chlorbenzophenon on currents, GAMK-activated in isolated neurons Purkine were investigated. Is shown, that the presence galogene in 5-м a rule at different molecules provides practically complete recurrence of properties of benzophenone . Benzophenone and 2-aminobenzophenon rendered the minimal effect. The contribution outsunaptic receptors in synaptic transfer in hippocampus was investigated in conditions of the raised probability of emission glutamate by pharmacological methods. Was shown, that in these conditions the contribution outsunaptic receptors sharply grows. Is shown, that outsunaptic receptors differ from synaptic on the pharmacological properties. Research of these problems are especially urgent that the numerous pathological condition of a brain also are connected to infringement of normal work of glutamate transfer. Product Description popup.authors popup.nrat_date 2020-04-02 Close