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Information × Registration Number 0204U005560, 0104U005447 , R & D reports Title Conditional allocation N -Caderin as model for research of a cardiac arrhythmia popup.stage_title Head Kostecky I, Registration Date 14-06-2004 Organization Institute of molecular biology & genetics popup.description2 The purpose of activity - analysis of a role conditioned N-сaderin of intercellular interplays in development both operation of the adult myocardium and gears of development of a cardiac arrhythmia. In the work the biochemical, biophysical, electrophysiological and statistical methods utilised molecular-genetical, cytological. Designed by us the unique model of a conditional knockout N-сaderin in heart of mice for the first time has demonstrated hierarchy of relationships of structural components intercalyrn of disks. We establishe absolute relation between operation N-сaderin and support of structural integrity of the adult myocardium. Us is rotined, that the poor function N-сaderin can be the main cause of development of an arrhythmia at different pathologies of heart, such as a hypertonia of heart, cardiomyopathy and ischemic illness of heart. The further analysis of the gear arrhythmia-genesis, called by loss N-сaderin, has the relevant value for mining the new approaches of examination of the patients, which one qualify as this group of risk, and also for mining the new approaches of therapy arrhythmia-genesis5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close