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Information × Registration Number 0204U006155, 0103U001595 , R & D reports Title To develop new methods of the control of development of physiological adaptation, hypertension and concomitant pathology of internal organs under action toxicous and emotional stress on organism. popup.stage_title Head Samokhina L.M., Registration Date 29-07-2004 Organization Institute of therapy of Academy of medical science of Ukraine popup.description2 The evaluation of stress-reaction development with the use as criteria of proteinases activity, specific enzymes of tissue formation vasoconstrictor peptide - angiotensin II, of endothelium destruction, multifunctional calcium-dependent proteinases - calpains in rats at alcohol- dependent hypertension (toxic and emotional stress), at hypotonia and emotional stress of prolonged character has been carried out. It has been shown, that development of alcoholism and assosiated arterial hypertension in rats resulted in activation of destructive proteinases, decrease of limited proteolysis reactions intensity, elimination of proteinases from organism in complex with their inhibitors. At an emotional stress of prolonged character, when the hypertension is not induced, the contrast changes is shown to action of alcohol, that suggest the exhaustion of proteolysis at alcohol-dependent hypertension by toxic influence of alcohol. It has been shown, that calpains and cathepsin G activation had pathogenetic effects. At hypotonia more appreciable proteolysis activation is marked: increase of proteinases level against the background alpha-2-macroglobin decrease. Product Description popup.authors popup.nrat_date 2020-04-02 Close