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Information × Registration Number 0204U006159, 0101U000149 , R & D reports Title Improvement of pharmacotherapy of chronic heart failure on the basis of study of mechanisms of vascular tone neurohumoral regulation popup.stage_title Head Rudyk Yuriy Stepanovich, Registration Date 29-07-2004 Organization Institute of Therapy AMS Ukraine popup.description2 218 patients with сhronic heart failure (CHF) of II - IV fnctional classes were surveyed. The purpose of work - to study a role of neurohumoral mechanisms of regulation of vascular tone in development and progression of CHF, to develop the differential approaches to diagnostics, treatment and preventive maintenance of CHF depending on activity of neurohumoral systems of vasoregulation. The research methods included definition of the the vasoactive mediators levels by radioimmunoassay/immune-enzyme assays, echocardiography, methods of variational statistics. As a result of research it was marked, that the high levels of adrenalin, noradrenalin, angiotensin II, aldosteron, ANP and endothelin-1 concern to "malignant" criteria of CHF course. The high clinico-hemodynamic efficiency of enalapri , metoprolol and losartan in the patients with CHF was determined. It was shown, that metoprolol had the most pronounced effects on sympato-adrenal system, losartan - on rennin-angiotensin-aldosteron and antidiuretic systems, whereas enalapril appeared to most effective in regards to the levels of ANP, insulinresistance and endothelial function. According to features of neurohumoral mechanisms of vasoregulation the differential schemes of enalapril, metoprolol and losartan administration were developed. Product Description popup.authors popup.nrat_date 2020-04-02 Close