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Information × Registration Number 0204U006597, 0103U007705 , R & D reports Title Structure and functions of nicotinic acetylcholine receptors in lymphocytes: protential role of nicotine in immunity and in lymphocyte cancerogenesis popup.stage_title Head Komisarenko S.V., Registration Date 09-12-2004 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 Both B lymphocytes and bone marrow cells of mice were shown to express two subtypes of nicotinic acetylcholine receptor (nAChR). The role of nAChRs in immunity and hemopoiesis was studied using mutant mice "knockout" on the genes of a4, a7 or b2 nAChR subunits, as well as chimera mice, the immune system of which contained a part of nAChR knockout cells. It is shown that nAChRs regulated the ratio of myeloid and lymphoid cells in the course of hemopoiesis and favored the survival and expansion of T and B lymphocytes at the stage of antigen-specific receptor expression. nAChR expression increased the immune repertoire of B lymphocytes, but limited the strength of the antibody immune response. It is suggested that such effects may be mediated through the regulation of B cell receptor and co-stimulatory molecule CD40. Product Description popup.authors popup.nrat_date 2020-04-02 Close