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Information × Registration Number 0205U000404, 0102U000112 , R & D reports Title Determining radiomodifying properties of new microelement compositions based on coordination metal compounds. popup.stage_title Head Pilipenko M.I., Registration Date 27-01-2005 Organization Grigor'ev Institut for Medical Radiology popup.description2 Object of the research: coordination compounds of metals, connective tissue, single total x-ray exposure. Purpose of the research: To reveal the mechanisms of radiomodifying effect of new coordination compounds of metals and scientific substantiation of their application in prevention of post-radiation complications development. Methods of the research: Biochemical, biophysical, morphological, morphometric, mathematical statistics. Results and their novelty: A scheme of optimum dose regimen of application of coordination compounds of metals at exposure was worked out basing on the findings of the research. The data about collagen and its fractions amount in the lungs and skin of the rats allowed to establish a continuous activation of metabolism of the connective tissue due to total single x-ray exposure at doses of 4.0 and 6.2 Gy. Radiomodifying properties of the substance, its ability to normalize the correlation between the fractions of soluble collagen in the connective tissue matrix of the normaltissue in the early period after the exposure (days 3-14) were proven at a metabolic level. Administration of the substance allowed reducing accumulation of total collagen (mean 1.36 times) and prevented development of post-radiation fibrotic long-term changes in the normal tissue of the exposed organism. Antioxidant properties of the substance were proven. Its radioprotective effect manifested by reduction of lipid peroxidation intensity in the lungs (1.45 times) and the skin of the rats (1.68 times), normalizing the activity of superoxide dismutase and glutathione peroxidase in the tissues of the rats on days 3-7 and 30 after the exposure. It was established that coordination compounds of metals did not cause activation of Guerin's carcinoma growth, facilitated prolongation of the life span at local fractionated x-ray exposure at a total dose of 25 Gy. Degree of introduction: The finding of the research were reported in a patent № 68926А, 1 scientific article, 4 proceedings, 1 innovation, 2 reports. Recommendations as to the use of the research findings: The worked out methods of the use of the drug in prevention and treatment of radiation lesions as well as the method of prevention of radiation-induced fibrosis can be introduced to the clinical practice. Area of application: Radiation medicine, radiology. Product Description popup.authors popup.nrat_date 2020-04-02 Close