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Information × Registration Number 0205U000407, 0103U000160 , R & D reports Title Mathematical simulation of the influence of transformation of DNA radiation lesions and their reparation on survival of the exposed cells popup.stage_title Head Knigavko V.G., Registration Date 27-01-2005 Organization Grigor'ev Institut for Medical Radiology popup.description2 Object of the research: DNA radiation lesions at exposure to ionizing photon radiation, processes of DNA radiation lesion reparation, survival of the exposed cells. Purpose: basing on the new hypotheses about the correlation between DNA radiation lesion transformation and their reparation in the exposed cells and survival of these cells, to build new mathematical models of the processes of radiation cell death, which allow to take into consideration the influence of these processes of the functional cell activity and some modifying factors. Methods of the research: methods of mathematical simulation. Results: Mathematical models of the processes were built: formation of survival curves, at exposure to x-rays and gamma-radiation with the account of the effects of saturation of cellular reparative systems; formation of large one-thread lesions and their transformation into two-thread DNA lesions in the exposed cells; processes of formation, transformation, and reparation of one-thread DNA lesions in theexposed cells. Novelty: a new hypothesis about the nature of the effect of saturation of cellular systems of radiation lesion reparation was formulated; for the first time, transcription hypothesis of forming one-thread large DNA lesions in the exposed cells was formulated and substantiated; all mathematical models of various biological processes built in the work are new. Area of application: radiobiology. Product Description popup.authors popup.nrat_date 2020-04-02 Close