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Information × Registration Number 0205U000817, 0102U003439 , R & D reports Title Evolutionary aspects of the regulation of free-radical processes in living organisms by iron ions popup.stage_title Head Lushchak Volodymyr Ivanovich, Registration Date 14-02-2005 Organization Precarpathian university named after Vassyl Stefanyk popup.description2 The effects of elevated iron ion concentrations on the growth of Escherichia coli and yeast Saccharomyces cerevisiae as well as on the pro/antioxidant status of yeast and fish have been investigated. Iron sulphate caused a shortening of lag-phase of E.coli growth and enchanced cell division. Iron ions resulted in oxidation of cell proteins and lipids and stimulated antioxidant enzyme activation in vivo. In model objects iron ions led to cell protein carbonilation which may be a reason of inactivation of some antioxidant enzymes probably due to hydroxyl radical generation in the Fenton reaction that is catalyzed by iron ion. It has been studied properties and physiological functions of heme-contained enzyme catalase in bacteria, yeast and animals. It was concluded that this enzyme protects cell proteins against oxidative damage and its function may be only partially compensated by other antioxidant mechanisms. Product Description popup.authors popup.nrat_date 2020-04-02 Close