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Information × Registration Number 0205U002104, 0102U002285 , R & D reports Title To study clinico-pathogenetic features of osteoarthrosis in adolescents for raising the effectivity of treatment measures popup.stage_title Head Lebets Irina Stepanivna, Доктор медичних наук Registration Date 28-01-2005 Organization Institute of Children and Adolescents Health Care of AMS of Ukraine popup.description2 Subject: 86 adolescents with osteoarthrosis. Objective: improvement of diagnosing osteoarthrosis in adolescents on the basis of studying clinico-immunologic manifestations of the disease and disorders in connective tissue metabolism. Methods: clinico-laboratory (immunologic and biochemical). Theoretical and practical results, novelty: osteoarthrosis in adolescents was characterized clinically und rentgenologically. It was determined that in adolescents take place significant disorders in proteoglycanes and collagen metabolism. Close interrelation was revealed between collagen and proteoglycanes metabolism and activation of acid and alkaline phosphatases. There was proved the influence of cytokines and immunologic shifts on osteoarthrosis development. There was established the role of disorders in interaction between connective tissue metabolism and immune system. Differential and diagnostic algorithm was worked out and most informative diagnostic symptoms of osteoarthrosis were determined in adolescents. Effectiveness: the results obtained will facilitate timely osteoarthrosis diagnosis in adolescents and prescription of appropriate therapy. Field of application: polyclinics for children and adults, cardiorheumatologic clinics and cardiorheumatologic departments of in-patient clinics. Product Description popup.authors popup.nrat_date 2020-04-02 Close