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Information × Registration Number 0205U002110, 0100U002731 , R & D reports Title Studying of a pathogenetic bases at myelodysplastic syndrome. popup.stage_title Head Isakova L.M., Registration Date 27-01-2005 Organization Kiev Research Institute of Haematolojy and Blood Transfusion popup.description2 Object of research: MDS patients, cell of a PB and BM, serum and plasma of blood. The methods: common haematologic, cytochemical, immunologic, cytogenetic, flow cytometry and submicroscopy. It is established: the concept about a role apoptosis of hemopoietic cells is confirmed as the key mechanism of a pathogenesis of MDS. The high apoptosis level in cells of a stromal microenvironment of BM, lymphocytes and granulocytes PB and BM is found. The role of balance between pro- and antiapoptotic markers of hemopoietic cells is shown at the different forms of MDS. The role of complex infringements of immunity, biochemical parameters, and also numerous of chromosomal anomalies in a pathogenesis of MDS established. The prognostic features of transformation of MDS in AML are designated. Social-medicine effect. Medicine. Product Description popup.authors popup.nrat_date 2020-04-02 Close