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Information × Registration Number 0205U004083, 0100U004335 , R & D reports Title Study of molecular mechanisms of interaction of a DNA-genomic viruses with a cell as the precondition of development of ways ethiotropic therapy and specific diagnosis of the diseases, caused by them popup.stage_title Head Nesterova N.V., Registration Date 25-02-2005 Organization Zabolotny Institute of Microbiology and Virology Ukrainian NAS popup.description2 Object of investigation - human adenoviruses, Epstain-Barr (EPB) virus and herpes simplex virus type 1. Methods of investigation: virological, molecular biological and immunochemical. It was determined the range of indeces, that characterize a EPB virus and adenovirus genome state in transplantable lines of B- and T- lymphoblastoid cells under conditions of mono- or mixed infection. It was received data that is important for undestanding of mechanism of viruses and lymphocytes interaction and reveal new aspects of influence of viral infection at the infected cell genome. It was investigated cytotoxic and antiviral properties of 7 new 6-azacytidine derivatives - the effect inhibitor of adenoviruses, EPB virus and herpes simplex virus 1 reproduction. It was elaborated specific componentry that formed a basis for constructing of ELISA test system for determination of antibodies to EPB virus. It was optimized a conditions of leading of ELISA and characterized a specificity and perceptibility "ELISA-atEBV-strip" test system. Field of application - medicine. Product Description popup.authors popup.nrat_date 2020-04-02 Close