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Information × Registration Number 0205U004821, 0103U003464 , R & D reports Title Functional properties and regulation of prostate cell's volume-activated anion conductance. popup.stage_title Head Lukyanetz Elena O., Доктор біологічних наук Registration Date 31-05-2005 Organization International center of molecular physiology popup.description2 We have revealed the direct inhibitory influnce of Ca -cheating agents, potentiating effect of intracellular trypsin and comple[ effect of e[tracellular pH on swelling-activatd CI-current ( ICI-zwell) in LNCfP human prostate cancer cells. Neuroendocrine(NE) differention of LNCaP cell and enhanced RVD. This occurred due both to the increased endogenous expression of CIC-3, which is a volume-sensitive CL-channel involved, as we show, in ICI, swell in LNCaP cell and also due to weaker negative ICI swell control by Ca2= entering via store-dependet pathways. Our ersults suggest that strenheng the mecaninism that helps to maintain volume constancy, may contribute to better survial rates of apoptotis-resistant NE cells. Product Description popup.authors popup.nrat_date 2020-04-02 Close