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Information × Registration Number 0205U006700, 0101U007982 , R & D reports Title Mechanism of the opioid reception popup.stage_title Head Kazakov Valery Nі, Registration Date 14-12-2005 Organization Donetsk state medical University named after M. Gorky popup.description2 Research object: rats Purpose of work: On the basis of opening of physiology machinsm of action of comenovoi acid on molecular one, membrane and on the system the levels to ground conception of a new approach to the ingibition of the morphine withdrawal, based on etiologic principle. The results: The tested hypothesis about the alternative way of the membrane signaling from opioid to the receptor to efectorou not through G-protein, and through oubain-dependent to natriy-dependent АТФ-element. The got new knowledges about metabolic transformations of comenic acid in different fabrics of organism, about its co-operation with endogenous opioid peptides. The created theoretical base for the use of comenic acid as an antiwithdrawal mean at inhibitioni morphine withdrawal. Novelty: First 1) the considered question of marketability alternative way of co-operation of comenic acid with the membrane of cage, in which by a mediator between a receptor and efectorom would be plazmatic natriy-dependent АТФ-element.Absence of influencing of comenic acid is led to on plazmatic АТФ-elements (in particular, natriy-dependent and calcium); 2) data about metabolic transformation of comenici acid in an organism are got. Set, that she metabolizoue in a liver and brain, but in a peripheral blood. Possibility of enzym and not enzym formation of new connections is exposed in a liver under action of this matter. It is led to, that comenic acid does not affect the structure of endogenous opiats. First the developed scientific conception of ingibition withdrawal, which is based on the etiopatogenetichnih features of disease. Product Description popup.authors popup.nrat_date 2020-04-02 Close