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Information × Registration Number 0206U000163, 0101U000603 , R & D reports Title Investigations of deep physico-chemical mechanisms of elementary processes in protein-nucleic acid recognition popup.stage_title Head Hovorun Dmytro, Registration Date 17-01-2006 Organization Institute of molecular biology & genetics popup.description2 For the first time convincing experimental and theoretical evidences are produced that elementary processes of protein-nucleic acid recognition at the level of point contacts "nucleic base - amino acid residue" may come out from the framework of Koshland classic model of structural-dynamical adaptation of recognizing sites and be accompanied by change of a base tautomeric state, which may be influenced by metal ions as well. Reliable quantum-chemical substantiation of Watson-Crick classical model of then role of prototropic tautomers of DNA bases in spontaneous mutagenesis. It was shown that thymine affinity to quanine enolic form exceeds its "complementatory" affinity and adenine affinity to cytosine iminoform is close to its affinity to thymine. Product Description popup.authors popup.nrat_date 2020-04-02 Close