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Information × Registration Number 0206U000167, 0101U000360 , R & D reports Title The investigation of signal trunsduction at malignant transformation and determination of novel tumor-associated antigens popup.stage_title Head Filonenko Valeriy Viktorovitch, Gout Ivan Tarasovitch, Registration Date 17-01-2006 Organization Institute of molecular Biology and Genetic popup.description2 A new mitogen-dependent kinase of ribosomal protein S6 - S6K2 have been identified and characterize. The mechanism of the regulation of nuclear/cytoplasmic localization of S6K2 mediated by PKC has been described. The number of new S6K binding partners have been identified by yeast two hybrid system and the functional links between partner proteins were analyzed. The expression profile and subcellular localization of S6K in human tumor cells have been studied. An increased expression and accumulation of S6K1 and S6K2 in the nuclei of malignant cells have been found in different types of human tumors. New tumor-associated antigens have been identified and analyzed by SEREX approach. Product Description popup.authors popup.nrat_date 2020-04-02 Close