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Information × Registration Number 0206U004118, 0103U000408 , R & D reports Title Studies of the mechanismes of endothelial- smooth muscle interaction and nitric oxide role in C- & Rho- kinase and cGMP- independent pathways of intracellular Са2+ regulation in animals with arterial hypertension. popup.stage_title Head Stefanov A.V., Soloviev A.I., Registration Date 13-02-2006 Organization Institute of Pharmacology and Toxicology Academy of Medical sciences of Ykraine popup.description2 It is established, that acetylcholine-induced relaxations were smaller in tissues obtained from hypertensive animals (genetically determined hypertension and experimental arterial hypertensions) than in those from healthy rats. Contractile responses from intact and permeabilized hypertensive rat thoracic aortic rings increased significantly compared with control. These effects are dependent on activation of protein kinase C and aren't dependent on activation Rho- kinase. Product Description popup.authors popup.nrat_date 2020-04-02 Close