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Information × Registration Number 0206U004127, 0103U000787 , R & D reports Title The expression of cell cycle regulators p53 and p21 in malignant tumours of female reproductive system popup.stage_title Head Buchynska L.G., Registration Date 13-02-2006 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Along with high proliferative activity and TP53 overexpression in endometrial and ovarian carcinomas, key feature for worsening prognosis for disease is low p16MTS/INK4a expression level for endometrial adenocarcinomas, lowering of p21WAF1/CIP1 level and significant increase of p16MTS/INK4a for ovarian cystadenocarcinomas. It has been found that expressional profile (Ki-67, p53, p21, p16) of tumors reflects the genetical geterogeneity of endometrial and ovarian neaplasms. In the case of endometrial carcinomas the considereble characteristic pathogenesis is gormonal background and in the case of ovarian serous carcinomas along with last factor are viruses and other factors as well. Product Description popup.authors popup.nrat_date 2020-04-02 Close