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Information × Registration Number 0206U004133, 0103U000780 , R & D reports Title Investigation role of exogenic nitric oxides in nitrosative stress development and their involvement in rising of cancer risk. popup.stage_title Head Mikhailenko Victor Mikhailovich, Registration Date 13-02-2006 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Nitrosativе stress (NS), caused by inhalation of nitrogen oxides, is accompanied by increased level of nitrosothiols in blood, the DNA damage and decline of the cellular energetic status in liver, negatively influenced on the T-chain of the immune system, violated balance of the free radicals processes and caused formation of carcinogenic nitrosocompounds. Growth of the Geren carcinoma under NS is accompanied by more aggressive growth of tumors and increased macrophages activity. In tumor tissue the level of apoptotic cells, activity of xanthineoxidase enzyme and lipid peroxidation was reduced. Product Description popup.authors popup.nrat_date 2020-04-02 Close