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Information × Registration Number 0206U004255, 0101U007196 , R & D reports Title Cell-free system of neurosecretion, presynaptic effect of neurotropic and psychopharmacological preparations popup.stage_title Head Trykash I.O., Registration Date 16-02-2006 Organization Palladin Institute Biochemastry of National Academy of Sciences of Ukraine popup.description2 The effect of antiepileptic drug ethosuximide and sodium valproat on fusion of synaptic vesicles with synaptosomal plasma membranes was studied in cell-free system. It was shown thet ethosuximide and sodium valproat increases the rate of Ca2+ -dependent fusion reaction in vitro. We have found thet convulsant drugs pentilenetetrazol and picrotoxin did not fuse membrane components of model system.Ethosuximide- and sodium valproat-provoked fusion of synaptic vesicles and plasma membrsnes of synaptosomes was suppressed by convulsant drugs pentylenetetrazol and picrotozin Product Description popup.authors popup.nrat_date 2020-04-02 Close