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Information × Registration Number 0206U004383, 0103U000649 , R & D reports Title Study of mechanisms and development of the methods of prevention and treatment of bone and muscular diseases (osteoporosis and its complica-tions, osteoarthritis of big joint, osteochondrosis) of women in postmenopausal period popup.stage_title Head Povoroznjuk Vladislav V., Registration Date 20-02-2006 Organization Institute of Gerontology Acad. Med. Sci Ukraine popup.description2 S u m m a r y Aim of the research: on the basis of experimental and clinical researches of the mechanisms of development of estrogenic deficiency on forming of pathology of bone-muscular system to develop the new diagnostic algorithms and treatment complex for patient in postmenopausal period. Methods: questionnaire, orthopaedic examination, ultrasound densitometry, anthro-pometric method, X-ray methods, biochemical methods, estimation of factual feeding. In experimental research it was used histomorphometic method, study of biochemical and biomechanical bone properties. Results: The temp of bone loss in postmenopausal women depends on peculiarities of menstrual function, state of factual feeding, anthropometric peculiarities. This research brought out the important negative role late menarche in forming the peak of bone mass, and early menopause in development of osteoporotic fractures and osteoarthritis of knee. Study of anthropometric indexes in postmenopausal women with osteoarthritis of big jointsshows the important role of obesity in its development and progressing, specially for osteoarthritis of knee joints. The feeding ration of Ukrainian postmenopausal women characterizes polinutrinutrient deficit. 34,3% the women use less than 700 calcium mg/d, and 46,5% less than 400 mg/d (Recommended Norma - 1000-1500 mg/d). It was established, that calcium vitamin D drugs (Ostein, Calcemin advance, Osteogenon) are effective in prevention of postmenopausal osteoporosis. Livial, Miacalcic, Endocalcin are effective in treatment of postmenopausal osteoporosis. They significant improve biomechanical properties of bone, positively influence on changes in biochemical markers of bone metabolism, contribute to underestimation of pain syndrome, to rise of functional possibilities of patients. Product Description popup.authors popup.nrat_date 2020-04-02 Close