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Information × Registration Number 0206U004433, 0103U000655 , R & D reports Title Functional state of endothelium in physiological aging and in the presence of cardiovascular pathology, peculiarities of the correction of endothelial dysfunction in elderly persons popup.stage_title Head Korkushko Oleg Vasilievich, Registration Date 22-02-2006 Organization Institute of Gerontology Acad. Med. Sci Ukraine popup.description2 Aim of the study: To study the functional state of endothelium in healthy elderly persons and in patients with cardiovascular pathology, and develop ways of correction of endothelial dysfunction taking account of age-related peculiarities of organism's state and course of diseases. The object of the study are healthy persons aged 20 to 29 years, 60 to 74 years, patients with coronary heart disease (CHD), hypertension, cardiac insufficiency aged 60 to 74 years, subjects with disturbed glucose tolerance and disturbance of lipid metabolism. Methods: To determine vasomotor, antithrombotic, antiinflammatory, antioxidant activity of vascular endothelium, aggregation activity of platelets, hemorheologic indices, indices of free-radical oxidation system, cytokins. Object of the study: Vascular endothelium It has been established. As a result of a study of the functional state of vascular endothelium in healthy elderly people - that vasomotor activity of endothelium is decreasing with age. A disturbance of functional state of endothelium in elderly patients with cardiovascular pathology is more pronounced as compared to healthy persons of the same age. The peculiarities of the effect of specific groups of drugs on the functional state of endothelium and hemorheologic indices have been elucidated. The advisability has been shown, of a differential approach to the use of drugs having an endothelium-protective effect depending on the peculiarities of their effect on the hemorheologic indices. Product Description popup.authors popup.nrat_date 2020-04-02 Close