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Information × Registration Number 0206U004438, 0102U001417 , R & D reports Title Studies on the role of the immune system in the structure-functional disturbances of the bone remodeling during aging popup.stage_title Head Butenko Gennadii Mihailovitch, Registration Date 22-02-2006 Organization Institute of Gerontology Acad. Med. Sci Ukraine popup.description2 Thymus removal in neonatal mice leads to the reduction of bone density. Thymus removal in oldest mice, or neonatal thymus grafting to young or old mice, did not lead to bone density changes. This fact testifies on existence of the thymus immuno-modulating effect on bone remodeling process only in neonatal life period. In human, the higher titer of antibody to DNA in the serum, and positive correlation between T cell concentration in the blood and frequency of bone fracture, were established in osteoporotic women. The high level of T cells in the blood and high titer of antibody to DNA in the serum may be markers or risk factors for bone fracture rise in postmenopausal women. Product Description popup.authors popup.nrat_date 2020-04-02 Close