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Information × Registration Number 0206U009243, 0104U000161 , R & D reports Title Obtaining of recombinant proteins: VPg and geterological eucaryotic initiation translation factors E4 and investigation their complexformation popup.stage_title Head Solomko Oleksandr Petrovich, Strokovskaya Ludmila Ivanivna, Registration Date 27-12-2006 Organization Institute of molecular biology & genetics popup.description2 We characterize the dissotiation constants for the interaction of the potato virus Y VPg with different plant eIF4Es and its isoforms and mapped the eIF(iso)4E attachment region on VPg. VPg/eIF4E interaction results in the inhibition of cell-free protein synthesis, and we show that it stems from the liberation of the cap moiety from the complex with eIF4E. Since VPg does not attach the cap, it appears that VPg induces changes in the eIF4E structure, diminishing its affinity to the cap. Product Description popup.authors popup.nrat_date 2020-04-02 Close