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Registration Number

0206U009247, 0104U000436 , R & D reports

Title

Molecular foundations of Genome functioning and him regulation

Head

Matsuka Gennadii, Rynditch Alla,

Registration Date

27-12-2006

Organization

Institute of molecular biology & genetics

Description

Processing of molecular models for studying functioning genome higher organisms at different levels expression genes is lead. The structurally functional organization of the certain sites genome, separate genes, change of some genes at a level of corresponding fibers is studied at differentiation and dedifferentiation cells of higher organisms. It is investigated on corresponding models some molecular mechanisms expression genome in norm and at genetically caused pathologies. Separate sites of regulation of functioning genome at a level replication, transcriptions, processing, translation m RNA are investigated. On the basis of the lead molecular-genetic researches a number of modern biotechnologies, methods of genic therapy and diagnostic systems is developed for the pathologies most dangerous to the person.

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