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Information × Registration Number 0207U000134, 0104U000408 , R & D reports Title Researtch biomolecular and genetic changes glial and mesenhymal intracranial tumors of swellings and spot their diagnostic and prognostic value popup.stage_title Head Zozulia Yury, Registration Date 10-01-2007 Organization Academician A.Romodanov Institute of neurosurgery AMSc of Ukraine popup.description2 Glial tumours of miscellaneous gystogenesis and degrees anaplasia even in one grup to the form - heterogeneous. In borders of one unit hige grade glial there are different structural zones. With increase anaplastic glial tumours the area which borrow mitochondrial structures in cytoplasm of their cells authentically decreases. It is revealed 117 genes, the level expression which in glioblastomas with the control changes more than in 5 times which can be used for molecular subtiping tumours. Reduction to a level expressoni all mitochondrial genes in glioblastomas compared with the control typically for high malignant gliomas (displays metabolysmus features glioblastomas). The quantity of genes, expression which activated in astrocytomas, increases with a progression of tumours. 24 genes, expression which activated in mitochondrial can be molecular markers of a malignant progression astrocytic tumours. It is proved, that gene HC gp-39/YKL-40 is the important marker of therapeutic sensitivity and genetic subtypes glioblastomas and can play oncogen a role. For the first time high production specific transcript a gene ІGF-ІІ in meningiomas is revealed; - ІGF-іі-associated РНК can be they a molecular marker. It is established, that in patients with glioblastoma and anaplastic astrocytomas pressed down production of active forms of oxygen monocytic peripheral blood, and the level of spontaneous production superoxigen anion to a radical is reduced. In gliomas contents Hoechst 33342 + apoptotic cells decrease with increase of their degree anaplasia. The raised level expression antigene S-100 in a fabric higt grade glial end differentiated meningiomas. It is established statistically authentic increase of frequency of aberrations of chromosomes and a level aneuploid cells in lymphocitic peripheral blood of patients with glial tumours Product Description popup.authors popup.nrat_date 2020-04-02 Close