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Information × Registration Number 0207U002536, 0106U001614 , R & D reports Title To determine a role of blood genetic systems and some molecular-genetic markers of tumoral clones in a complex estimation of efficiency of a transplantation stem hemopoietic cells at patients leukemias and lymphomas popup.stage_title Head Bebeshko Vladimir Grigorovich, Доктор медичних наук Registration Date 05-02-2007 Organization Research Centre for Radiation Medicine popup.description2 Object: children and adults with leukemias and lymphomas. The purpose: creation the criteria of system for an estimation of transplantation efficiency of hemopoietic stem cells and prediction of the further current of leukaemias and lymphomas on the basis of phenotyping association of blood genetic systems, cytogenetic, immunogenetic and some molecular-genetic markers of tumoral clones with clinical features of diseases. Methods: clinical, hematological, immunogenetic, cytogenetic and molecular-genetic. On the basis of the analysis of features of disease current and results of therapy of 204 patients with the oncohematological pathology, 97 from which it has been carried out transplantation hemopoietic stem cells, the complex clinical, laboratory, immune- and molecular-genetic criteria are developed, and also is determined them prognostic the importance in an estimation of efficiency of bone marrow transplantation. It is established, that current and efficiency of treatment the oncohematological diseases at the surveyed contingent with use of stem cells transplantation is in interrelation with cytokine a background, determined molecular-genetic and cytogenetic infringements, immunogenetic markers of blood, and also dermatoglific characteristics. Product Description popup.authors popup.nrat_date 2020-04-02 Close