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Information × Registration Number 0207U002539, 0104U003628 , R & D reports Title Study of clinical-metabolic disorders genesis regularities under leptinresistance and insulinresistance syndromes, osteopenia and bodyweight changes in ChNPP accident survivors and their children in remote terms (18-20 years after) popup.stage_title Head Kovalenko A.N., Registration Date 05-02-2007 Organization Research Centre for Radiation Medicine popup.description2 Study subject: the ChNPP accident survivors (emergency workers of 1986/1987 period, evacuees, residents of contaminated territories) having leptinresistance, insulinresistance and osteopenic syndromes both with body mass abnormalities aged 14-45 at the time of accident (210 persons), their children born in 1987-1993 (138 kids); 348 persons in total. Objective: studying the clinic/metabolic disorders in survivors of the ChNPP accident having leptinresistance, insulinresistance and osteopenic syndromes both with body mass abnormalities and in their children; elaboration of respective diagnostic criteria and curative-rehabilitation tools. Methods: routine clinical, laboratory, instrumental, anthropometric, biochemical, hormonal, densitometry, ultrasound scanning, rheovasography, statistical. Insulinresistance and leptinresistance syndromes are formed under the body mass excess and are followed by adipose tissue functional activation with hyperproduction of leptin and some hormones of other origin i.e. insulin, C-peptide, parathyroid hormone and cortisol, along with serum glucose, triglycerides, cholesterol and bata-lipoproteides elevation. Low BMI in children and normal value of the index in adults is an important risk factor for osteopenic syndrome, whereas body mass elevation or obesity on the contrary provides BMD preservation through the intense secretion of osteoprotective hormones i.e. leptin, insulin and parathyroid hormone along with calcitonin synthesis lowering. BMD decrease (i.e. osteopenic syndrome) is observed in remote terms upon the exposure in emergency workers having high radiation doses (0.5-7.1 Gy), severe abnormality (osteoporosis) is found in 6% of cases. Field of application: radiation medicine, clinical endocrinology. Application mode: publications, reports at conferences. Efficacy: improve of diagnostics of endocrine-induces metabolic disorders. Leptinresistance, insulinresistance, osteopenia, obesity, dyslipidemia, ionizing radiation, ChNPP accident. Product Description popup.authors popup.nrat_date 2020-04-02 Close