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Information × Registration Number 0207U002837, 0105U002214 , R & D reports Title Molekular mechanisms of regulation of morphological and functional state of plateletes under the 1 type diabetes mellitus popup.stage_title Head Sybirna N., Registration Date 19-02-2007 Organization Ivan Franko Lviv National University popup.description2 . Differential changes in pattern of proteins which bind to these G-proteins in diabetic platelets have been revealed. Obtained results suggest that signalling pathways mediated by Rho GTPases are altered under type I diabetes mellitus.It was found that incubation of platelet rich plasma with wortmannin, an irreversible selective inhibitor of phosphoinositide 3-kinase (PI3K), leads to sharp drop in platelet aggregation ability in healthy donors, whereas in type 1 diabetes mellitus patients this effect was less manifested or not quite determined. Translocation dynamics of PI3K regulatory subunit into cytoskeleton fraction under induction of platelet aggregation by various ADP concentrations and after wortmannin treatment was studied. Іnteraction of endothelial constitutive NO synthase with PI3K in mechanisms of platelet functional state regulation under studied pathological and normal conditions have been analyzed. Product Description popup.authors popup.nrat_date 2020-04-02 Close