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Information × Registration Number 0207U004586, 0102U000628 , R & D reports Title Estimation of vitamins, coenzymes and their proteins -acceptors interaction mechanisms in regulatins intracellar metabolism both in the norm and pathology popup.stage_title Head Donchenko Georgiy, Registration Date 08-05-2007 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 Mechanisms of the A, B1, E, D3, PP vitamins functioning, their biologically active derivates, coenzymes (thiamin-phosphates, of nicotinamides) and their specific protein-aссeptors in the designated cells have been investigated. Alfa-T with the free OH-group of the chromane nucleus manifested significant inhibitory effect on the apoptosis inducted by the actinomycin D, and while modeling necrosis under influence of the big concentrations of the ionophore A23187 it was partially transferring necrotic mode of the thymocytes' destruction into apoptotic. Alfa-TC6 administrated per os to the mice of the C57BL/6 line reduces growth of the Lewis carcinomas (LL) in 55.9% (most nearly as cis-platinum) and administrated in complex with cis-platinum promotes inhibiting effect of the mentioned medication on the quantity of the metastases, which appear in the lungs of mice. Two compositions of the medications for the activation of the Q biosynthesis, functioning of the Q-dependent redox enzymes within the transfer chain of the mitochondrion's electrons and ferment system of the AO protection of the organism have been created. Product Description popup.authors popup.nrat_date 2020-04-02 Close