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Information × Registration Number 0207U004952, 0104U009681 , R & D reports Title Inhibitors of nonspecific phosphatases: chemical design and mechanisms of influence in model biochemical systems popup.stage_title Head Vovk A.I., Registration Date 25-10-2007 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 The original direction of alkaline phosphatase inhibitors design with use of a macrocyclic platform for covalent binding of phosphonic acid residues is grounded. The potential of aminophosphonic acids on calix[4]arenes platform as effective inhibitors of bovine intestinal alkaline phosphatase and bovine kidney alkaline phosphatase is shown. For the first time stereochemical features of bovine kidney alkaline phosphatase inhibition by calix[4]arene-?-аminophosphonic acids are established. On the basis of molecular docking results the mechanisms of interaction of macrocyclic inhibitors with alkaline phosphatase are proposed.5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close